ARG45449
anti-EDEM3 antibody
anti-EDEM3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes EDEM3 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | EDEM3 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human EDEM3. |
| 偶联标记 | Un-conjugated |
| 別名 | EDEM3; ER Degradation Enhancing Alpha-Mannosidase Like Protein 3; C1orf22; ER Degradation-Enhancing Alpha-Mannosidase-Like Protein 3; ER Degradation Enhancer, Mannosidase Alpha-Like 3; Alpha-1,2-Mannosidase EDEM3; ER Degradation-Enhancing -Mannosidase-Like Protein 3; ER Degradation-Enhancing Alpha-Mannosidase-Like 3; Chromosome 1 Open Reading Frame 22; EC 3.2.1.113; CDG2V |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 105 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9BZQ6 Human ER degradation-enhancing alpha-mannosidase-like protein 3 |
|---|---|
| 基因名称 | EDEM3 |
| 全名 | ER Degradation Enhancing Alpha-Mannosidase Like Protein 3 |
| 背景介绍 | Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008] |
| 生物功能 | Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. [UniProt] |
| 细胞定位 | Endoplasmic reticulum. [UniProt] |
| 预测分子量 | 105 kDa |
| 翻译后修饰 | Glycoprotein. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG45449 anti-EDEM3 antibody IHC-P image
Immunohistochemistry: Human appendiceal adenocarcinoma stained with ARG45449 anti-EDEM3 antibody at 2 μg/ml dilution.
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ARG45449 anti-EDEM3 antibody WB image
Western blot: K562 stained with ARG45449 anti-EDEM3 antibody at 0.5 μg/ml dilution.
