ARG10566
anti-EBV LMP1 antibody [D24-G]
anti-EBV LMP1 antibody [D24-G] for IHC-Formalin-fixed paraffin-embedded sections and EBV
概述
| 产品描述 | Rabbit Monoclonal antibody [D24-G] recognizes EBV LMP1 |
|---|---|
| 反应物种 | EBV |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | D24-G |
| 同位型 | IgG |
| 靶点名称 | EBV LMP1 |
| 抗原物种 | Virus |
| 抗原 | Synthetic peptide around the internal region of EBV's Latent Membrane Protein-1 |
| 偶联标记 | Un-conjugated |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 20 mg/ml BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | LMP1 |
|---|---|
| 全名 | LMP1 |
| 生物功能 | Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG10566 anti-EBV LMP1 antibody [D24-G] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded HRS cells of the classical Hodgkin Lymphoma (4 µm section) stained with ARG10566 anti-EBV LMP1 antibody [D24-G].
