ARG22410
anti-Dynorphin B antibody
anti-Dynorphin B antibody for IHC-Frozen sections,Radioimmunoassay and Mouse,Rat,Guinea pig,Hamster,Pig,Rhesus Monkey
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Dynorphin B This antibody recognizes dynorphin B, an endogenous opioid peptide, also known as rimorphin with the peptide sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr, derived from the sequential cleavage of pro-enkephalin B to form leumorphin which is, in turn cleaved to form dynorphin B (Devi et al. 1985). The cleavage of the dynorphin precursors to form the dynorphin neuropeptides is largely controlled by the serine protease cathepsin L which co-localizes with dynorphins in secretory vesicles of brain cortical neurons(Funkelstein et al. 2010) and prohormone convertase 2, a member of the furin, peptidate S8 family (Schwarzer 2009). Dynorphin b sequence is well conserved among mammal, avian (Youngren et al. 1993) and reptilian (Goldsmith et al. 1992) species. Rabbit anti Dynorphin b antibody is expected to have a wide species cross reactivity. |
|---|---|
| 反应物种 | Ms, Rat, Gpig, Hm, Pig, R. Mk |
| 预测物种 | Hu, Bov, Chimp, Dog, Glla, Hrs |
| 应用 | IHC-Fr, RIA |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Dynorphin B |
| 抗原物种 | Pig |
| 抗原 | Synthetic peptide, YGGFLRRQFKVVT, corresponding to full-length porcine dynorphin B (1-13), conjugated to thyroglobulin. |
| 偶联标记 | Un-conjugated |
| 別名 | Big Dyn; 1-8; Dynorphin B-29; Dynorphin B; ADCA; SCA23; Preprodynorphin; PENKB; Dyn-A17; 1-17; Proenkephalin-B; Dynorphin A; 1-13; Beta-neoendorphin-dynorphin; Dyn-B |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
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| 缓冲液 | PBS, 0.09% Sodium azide and 1% BSA. |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
GeneID: 100135596 Guinea pig PDYN |
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| 基因名称 | PDYN |
| 全名 | prodynorphin |
| 背景介绍 | The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010] |
| 生物功能 | Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect. [UniProt] |
| 预测分子量 | 28 kDa |
| 翻译后修饰 | The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. |
