ARG44653
anti-Dynamin antibody
anti-Dynamin antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human,Mouse
概述
| 产品描述 | Mouse Monoclonal antibody recognizes Dynamin |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | Dynamin |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | DNM1; Dynamin 1; DNM; EC 3.6.5.5; Dynamin-1; Dynamin I; Dynamin; DEE31A; DEE31B; EIEE31; DEE31 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Dynamin 1 |
| 全名 | DNM1 |
| 背景介绍 | This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| 生物功能 | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation. [UniProt] |
| 细胞定位 | Cell membrane, Cell projection, Coated pit, Cytoplasmic vesicle, Membrane, Microtubule, Synapse. [UniProt] |
| 预测分子量 | 97 kDa |
| 翻译后修饰 | Methylation, Nitration, Phosphoprotein. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG44653 anti-Dynamin antibody IHC-P image
Immunohistochemistry: Human Brain stained with ARG44653 anti-Dynamin antibody at 5 µg/mL dilution.
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ARG44653 anti-Dynamin antibody IP image
Immunoprecipitation: Mouse Brain lysate immunoprecipitated with 2.5 µg of ARG44653 anti-Dynamin antibody.
