ARG65435
anti-Drebrin antibody [DBN-N-03]
anti-Drebrin antibody [DBN-N-03] for CyTOF®-candidate,Flow cytometry,Western blot and Human
Cancer antibody; Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [DBN-N-03] recognizes Drebrin |
|---|---|
| 反应物种 | Hu |
| 应用 | CyTOF®-candidate, FACS, WB |
| 特异性 | The clone DBN-N-03 recognizes drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | DBN-N-03 |
| 同位型 | IgG2b |
| 靶点名称 | Drebrin |
| 抗原物种 | Human |
| 抗原 | Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326) |
| 偶联标记 | Un-conjugated |
| 別名 | Developmentally-regulated brain protein; D0S117E; Drebrin |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | WB: REH, Nalm-6 and HEK293. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from hybridoma culture supernatant by protein A-affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | TBS (pH 8.0) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DBN1 |
| 全名 | drebrin 1 |
| 背景介绍 | Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse. |
| 生物功能 | Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. [UniProt] |
| 研究领域 | Cancer antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 71 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG65435 anti-Drebrin antibody [DBN-N-03] WB image
Western blot: 1. REH cell lysate 2. Ramos cell lysate 3. Nalm-6 cell lysate stained with ARG65435 anti-Drebrin antibody [DBN-N-03].
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ARG65435 anti-Drebrin antibody [DBN-N-03] CyTOF image
CyTOF: Human brain tumor cells were stained with ARG65435 anti-Drebrin antibody [DBN-N-03] (152Sm). Singlet cells were gated for data analysis.
