概述

产品描述	Rabbit Polyclonal antibody recognizes Drebrin
反应物种	Hu, Ms, Rat
应用	ICC/IF, IP, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	Drebrin
抗原物种	Human
抗原	Synthetic peptide of Human Drebrin.
偶联标记	Un-conjugated
別名	Developmentally-regulated brain protein; D0S117E; Drebrin

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:50 - 1:200 IP 1:50 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	HeLa
实际分子量	~ 125 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1627 Human DBN1 GeneID: 56320 Mouse DBN1 GeneID: 81653 Rat DBN1 Swiss-port # Q07266 Rat Drebrin Swiss-port # Q16643 Human Drebrin Swiss-port # Q9QXS6 Mouse Drebrin More
基因名称	DBN1
全名	drebrin 1
背景介绍	The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
生物功能	Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. [UniProt]
细胞定位	Cytoplasm, cell cortex. Cell junction. Cell projection, growth cone. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters. Colocalized with DBN1, RUFY3 and F-actin at the transitional domain of the axonal growth cone. [UniProt]
预测分子量	71 kDa

检测图片 (1) Click the Picture to Zoom In