ARG42733
anti-Desmocollin 3 antibody
anti-Desmocollin 3 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Desmocollin 3 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Desmocollin 3 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide between aa. 822-850 of Human Desmocollin 3. |
| 偶联标记 | Un-conjugated |
| 別名 | Desmocollin-4; DSC4; DSC2; Cadherin family member 3; Desmocollin-3; DSC; CDHF3; DSC1; HT-CP |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | A431 | ||||
| 实际分子量 | ~ 95 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DSC3 |
| 全名 | desmocollin 3 |
| 背景介绍 | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| 生物功能 | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. [UniProt] |
| 预测分子量 | 100 kDa |
检测图片 (1) Click the Picture to Zoom In
-
ARG42733 anti-Desmocollin 3 antibody WB image
Western blot: 35 µg of A431 cell lysate stained with ARG42733 anti-Desmocollin 3 antibody at 1:1000 dilution.
