ARG58500
anti-Desmocollin 2 antibody
anti-Desmocollin 2 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Desmocollin 2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Desmocollin 2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 520-690 of Human Desmocollin 2 (NP_077740.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Desmosomal glycoprotein II; ARVD11; Desmosomal glycoprotein III; DSC3; Desmocollin-3; Desmocollin-2; DG2; CDHF2; DGII/III; Cadherin family member 2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | BT474 | ||||
| 实际分子量 | 105 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DSC2 |
| 全名 | desmocollin 2 |
| 背景介绍 | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| 生物功能 | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. [UniProt] |
| 细胞定位 | Cell membrane, Single-pass type I membrane protein, Cell junction, desmosome. [UniProt] |
| 预测分子量 | 100 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58500 anti-Desmocollin 2 antibody WB image
Western blot: 25 µg of BT474 cell lysate stained with ARG58500 anti-Desmocollin 2 antibody at 1:1000 dilution.
