概述

产品描述	Rabbit Polyclonal antibody recognizes DYRK1B
反应物种	Hu, Ms
应用	IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	DYRK1B
抗原物种	Human
抗原	KLH-conjugated synthetic peptide corresponding to aa. 561-589 (C-terminus) of Human DYRK1B.
偶联标记	Un-conjugated
別名	Dual specificity tyrosine-phosphorylation-regulated kinase 1B; MIRK; Minibrain-related kinase; EC 2.7.12.1; AOMS3; Mirk protein kinase

应用说明

应用建议	应用 推荐稀释比 IHC-P Assay-dependent WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Mouse kidney

属性

形式	Liquid
纯化	Purification with Protein G.
缓冲液	PBS and 0.09% (W/V) Sodium azide
抗菌剂	0.09% (W/V) Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 13549 Mouse DYRK1B GeneID: 9149 Human DYRK1B Swiss-port # Q9Y463 Human Dual specificity tyrosine-phosphorylation-regulated kinase 1B Swiss-port # Q9Z188 Mouse Dual specificity tyrosine-phosphorylation-regulated kinase 1B
基因名称	DYRK1B
全名	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
背景介绍	This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
生物功能	Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC). [UniProt]
细胞定位	Nucleus.
研究领域	Cancer antibody
预测分子量	69 kDa
翻译后修饰	Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.

检测图片 (1) Click the Picture to Zoom In