ARG58562
anti-DYRK1A antibody
anti-DYRK1A antibody for ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DYRK1A |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DYRK1A |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to 17 aa (near the C-terminus) of Human DYRK1A. |
| 偶联标记 | Un-conjugated |
| 別名 | Protein kinase minibrain homolog; MRD7; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; MNBH; DYRK; EC 2.7.12.1; DYRK1; Dual specificity YAK1-related kinase; HP86; hMNB; MNB |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa and K562 | ||||||
| 实际分子量 | 90 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q13627 Human Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|---|
| 基因名称 | DYRK1A |
| 全名 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
| 背景介绍 | This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] |
| 生物功能 | May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3. [UniProt] |
| 预测分子量 | 86 kDa |
| 翻译后修饰 | Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro). [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG58562 anti-DYRK1A antibody ICC image
Immunocytochemistry: HeLa cells stained with ARG58562 anti-DYRK1A antibody at 10 µg/ml dilution.
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ARG58562 anti-DYRK1A antibody WB image
Western blot: HeLa cell lysate stained with ARG58562 anti-DYRK1A antibody at 1 and 2 µg/ml dilution.
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ARG58562 anti-DYRK1A antibody WB image
Western blot: K562 cell lysate stained with ARG58562 anti-DYRK1A antibody.
