ARG58502
anti-DVL1 / Dishevelled 1 antibody
anti-DVL1 / Dishevelled 1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DVL1 / Dishevelled 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DVL1 / Dishevelled 1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 510-640 of Human DVL1 / Dishevelled 1 (NP_004412.2). |
| 偶联标记 | Un-conjugated |
| 別名 | DVL; DSH homolog 1; DVL1P1; DVL1L1; DRS2; Segment polarity protein dishevelled homolog DVL-1; Dishevelled-1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse heart | ||||||||
| 实际分子量 | 90 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DVL1 |
| 全名 | dishevelled segment polarity protein 1 |
| 背景介绍 | DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008] |
| 生物功能 | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). [UniProt] |
| 细胞定位 | Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytosol, Cytoplasmic vesicle. [UniProt] |
| 预测分子量 | 75 kDa |
| 翻译后修饰 | Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58502 anti-DVL1 / Dishevelled 1 antibody WB image
Western blot: 25 µg of Mouse heart lysate stained with ARG58502 anti-DVL1 / Dishevelled 1 antibody at 1:1000 dilution.
