概述

产品描述	Rabbit Polyclonal antibody recognizes DUSP6
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	DUSP6
抗原物种	Human
抗原	Synthetic peptide of Human DUSP6.
偶联标记	Un-conjugated
別名	Dual specificity protein phosphatase PYST1; MKP-3; MAP kinase phosphatase 3; MKP3; EC 3.1.3.16; PYST1; Dual specificity protein phosphatase 6; Mitogen-activated protein kinase phosphatase 3; EC 3.1.3.48; HH19

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	HeLa
实际分子量	43 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.3) and 0.02% Sodium azide.
抗菌剂	0.02% Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1848 Human DUSP6 Swiss-port # Q16828 Human Dual specificity protein phosphatase 6
基因名称	DUSP6
全名	dual specificity phosphatase 6
背景介绍	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
生物功能	Inactivates MAP kinases. Has a specificity for the ERK family. [UniProt]
细胞定位	Cytoplasm. [UniProt]
预测分子量	42 kDa

检测图片 (1) Click the Picture to Zoom In