ARG55202
anti-DRD4 / Dopamine Receptor D4 antibody
anti-DRD4 / Dopamine Receptor D4 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Neuroscience antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DRD4 / Dopamine Receptor D4 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DRD4 / Dopamine Receptor D4 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human DRD4 (NP_000788.2) |
| 偶联标记 | Un-conjugated |
| 別名 | D4DR; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse liver |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DRD4 |
| 全名 | dopamine receptor D4 |
| 背景介绍 | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008] |
| 生物功能 | Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). [UniProt] |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 44 kDa |
| 翻译后修饰 | Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein. |
检测图片 (2) Click the Picture to Zoom In
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ARG55202 anti-DRD4 / Dopamine Receptor D4 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse kidney stained with ARG55202 anti-DRD4 / Dopamine Receptor D4 antibody at 1:200 dilution.
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ARG55202 anti-DRD4 / Dopamine Receptor D4 antibody WB image
Western blot: Mouse liver tissue lysate stained with ARG55202 anti-DRD4 / Dopamine Receptor D4 antibody.
