ARG58514
anti-DRD3 / Dopamine Receptor D3 antibody
anti-DRD3 / Dopamine Receptor D3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DRD3 / Dopamine Receptor D3 |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Chk |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DRD3 / Dopamine Receptor D3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to a sequence at the C-terminus of Human Dopamine Receptor D3(352-367aa NTHCQTCHVSPELYSA), different from the related Rat and Mouse sequences by two amino acids. |
| 偶联标记 | Un-conjugated |
| 別名 | D3DR; ETM1; FET1; D(3) dopamine receptor; Dopamine D3 receptor |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: By heat mediation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DRD3 |
| 全名 | dopamine receptor D3 |
| 背景介绍 | This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008] |
| 生物功能 | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co- localize in lipid rafts of renal proximal tubule cells. [UniProt] |
| 预测分子量 | 44 kDa |
| 翻译后修饰 | Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma). [UniProt] |
检测图片 (2) Click the Picture to Zoom In
-
ARG58514 anti-DRD3 / Dopamine Receptor D3 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain stained with ARG58514 anti-DRD3 / Dopamine Receptor D3 antibody.
-
ARG58514 anti-DRD3 / Dopamine Receptor D3 antibody WB image
Western blot: Rat testis, Rat brain, U87 and HeLa lysates stained with ARG58514 anti-DRD3 / Dopamine Receptor D3 antibody.
