ARG54354
anti-DRAK1 antibody
anti-DRAK1 antibody for ICC/IF,Western blot and Human
Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DRAK1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 特异性 | This antibody recognizes human DRAK1 (50kDa). No cross-reactivity with DRAK2, DAP or ZIP kinases. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DRAK1 |
| 抗原物种 | Human |
| 抗原 | Peptide corresponding to aa 5-19 of human DRAK1 (accession no. Q9UEE5). |
| 偶联标记 | Un-conjugated |
| 別名 | EC 2.7.11.1; DRAK1; Serine/threonine-protein kinase 17A; DAP kinase-related apoptosis-inducing protein kinase 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | A431 and MOLT4 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UEE5 Human Serine/threonine-protein kinase 17A |
|---|---|
| 基因名称 | STK17A |
| 全名 | serine/threonine kinase 17a |
| 背景介绍 | Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis have been identified and designated DRAK1 and DRAK2 for DAP kinase–related apoptosis-inducing protein kinases. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases which mediate apoptosis through their catalytic activities. DRAK1 is located in cell nuclei, and the mRNA for DRAK1 is ubiquitously expressed in human tissues. |
| 生物功能 | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody |
| 预测分子量 | 47 kDa |
| 翻译后修饰 | Autophosphorylated. |
检测图片 (2) Click the Picture to Zoom In
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ARG54354 anti-DRAK1 antibody WB image
Western Blot: A:MOLT4; B:A431 stained with ARG54354 anti-DRAK1 antibody at 1 μg/ml dilution.
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ARG54354 anti-DRAK1 antibody ICC/IF image
MOLT4 stained with ARG54354 anti-DRAK1 antibody at 2 μg/ml dilution.
