ARG57931
anti-DPYD antibody
anti-DPYD antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DPYD |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DPYD |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-173 of Human DPYD (NP_001153773.1). |
| 偶联标记 | Un-conjugated |
| 別名 | DHP; DPD; DHPDHASE; Dihydropyrimidine dehydrogenase [NADP(+)]; DHPDHase; DPD; EC 1.3.1.2; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | THP-1 | ||||
| 实际分子量 | ~ 110 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q12882 Human Dihydropyrimidine dehydrogenase [NADP(+)] Swiss-port # Q8CHR6 Mouse Dihydropyrimidine dehydrogenase [NADP(+)] |
|---|---|
| 基因名称 | DPYD |
| 全名 | dihydropyrimidine dehydrogenase |
| 背景介绍 | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| 生物功能 | Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 111 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG57931 anti-DPYD antibody WB image
Western blot: 25 µg of THP-1 cell lysate stained with ARG57931 anti-DPYD antibody at 1:1000 dilution.
