ARG42609
anti-DOK1 / p62 Dok antibody
anti-DOK1 / p62 Dok antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DOK1 / p62 Dok |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DOK1 / p62 Dok |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-280 of Human DOK1 / p62 Dok (NP_001372.1). |
| 偶联标记 | Un-conjugated |
| 別名 | dok; p62; P62DOK; Docking protein 1; pp62; Downstream of tyrosine kinase 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DOK1 |
| 全名 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
| 背景介绍 | The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
| 生物功能 | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. [UniProt] |
| 细胞定位 | Isoform 1: Cytoplasm. Nucleus. Isoform 3: Cytoplasm, perinuclear region. [UniProt] |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42609 anti-DOK1 / p62 Dok antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human gastric cancer tissue stained with ARG42609 anti-DOK1 / p62 Dok antibody at 1:100 dilution.
