ARG45880
anti-DOCK3 / MOCA antibody
anti-DOCK3 / MOCA antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,Flow cytometry and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DOCK3 / MOCA |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DOCK3 / MOCA |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human DOCK3 / MOCA . |
| 偶联标记 | Un-conjugated |
| 別名 | Dedicator Of Cytokinesis 3; DOCK3; KIAA0299; MOCA; Dedicator of cytokinesis protein 3; Modifier of cell adhesion; Presenilin-binding protein; PBP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 233 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -22°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8IZD9 Human Dedicator of cytokinesis protein 3 |
|---|---|
| 基因名称 | DOCK3 |
| 全名 | Dedicator Of Cytokinesis 3 |
| 背景介绍 | This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010] |
| 生物功能 | Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity) [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 233 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG45880 anti-DOCK3 / MOCA antibody IHC-P image
Immunohistochemistry: Human colon cancer stained with ARG45880 anti-DOCK3 / MOCA antibody at 2 μg/ml dilution.
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ARG45880 anti-DOCK3 / MOCA antibody FACS image
Flow Cytometry: 293T stained with ARG45880 anti-DOCK3 / MOCA antibody at 1 µg/10^6 cells dilution.
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ARG45880 anti-DOCK3 / MOCA antibody WB image
Western blot: Rat brain stained with ARG45880 anti-DOCK3 / MOCA antibody at 0.5 μg/ml dilution.
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ARG45880 anti-DOCK3 / MOCA antibody WB image
Western blot: Mouse brain stained with ARG45880 anti-DOCK3 / MOCA antibody at 0.5 μg/ml dilution.
