ARG42118
anti-DNAJC5 / CSP antibody
anti-DNAJC5 / CSP antibody for Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DNAJC5 / CSP |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DNAJC5 / CSP |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-198 of Human DNAJC5 / CSP (NP_079495.1). |
| 偶联标记 | Un-conjugated |
| 別名 | mir-941-5; mir-941-4; CLN4B; Ceroid-lipofuscinosis neuronal protein 4; mir-941-3; mir-941-2; DNAJC5A; Cysteine string protein; DnaJ homolog subfamily C member 5; CLN4; NCL; CSP |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse liver | ||||
| 实际分子量 | ~ 30 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DNAJC5 |
| 全名 | DnaJ (Hsp40) homolog, subfamily C, member 5 |
| 背景介绍 | This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010] |
| 生物功能 | Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). [UniProt] |
| 细胞定位 | Membrane; Lipid-anchor. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. [UniProt] |
| 预测分子量 | 22 kDa |
| 翻译后修饰 | Fatty acylated (By similarity). Heavily palmitoylated in the cysteine string motif (By similarity). Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58 (PubMed:27452402). This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions (PubMed:27452402). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42118 anti-DNAJC5 / CSP antibody WB image
Western blot: 25 µg of Mouse liver lysate stained with ARG42118 anti-DNAJC5 / CSP antibody at 1:1000 dilution.
