ARG45195
anti-DNAJC10 antibody
anti-DNAJC10 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DNAJC10 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DNAJC10 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human DNAJC10. |
| 偶联标记 | Un-conjugated |
| 別名 | DNAJC10; DnaJ Heat Shock Protein Family (Hsp40) Member C10; ERdj5; PDIA19; Endoplasmic Reticulum DNA J Domain-Containing Protein 5; Protein Disulfide Isomerase Family A, Member 19; DnaJ (Hsp40) Homolog, Subfamily C, Member 10; DnaJ Homolog Subfamily C Member 10; ER-Resident Protein ERdj5; Macrothioredoxin; MTHr; J-Domain-Containing Protein Disulfide Isomerase-Like Protein 3; EC 1.8.4.-; ERDJ5; JPDI_x000D_ |
应用说明
| 应用建议 |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | 91 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DNAJC10 |
| 全名 | DnaJ Heat Shock Protein Family (Hsp40) Member C10 |
| 背景介绍 | This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012] |
| 生物功能 | Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.. [UniProt] |
| 细胞定位 | Endoplasmic reticulum. [UniProt] |
| 预测分子量 | 91 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein. [UniProt] |
检测图片 (6) Click the Picture to Zoom In
-
ARG45195 anti-DNAJC10 antibody IHC-P image
Immunohistochemistry: Human gastric cancer stained with ARG45195 anti-DNAJC10 antibody at 2 μg/ml dilution.
-
ARG45195 anti-DNAJC10 antibody ICC/IF image
Immunofluorescence: A431 stained with ARG45195 anti-DNAJC10 antibody at 5 ug/ml dilution.
-
ARG45195 anti-DNAJC10 antibody WB image
Western blot: Hela, HEPG2, and U87 stained with ARG45195 anti-DNAJC10 antibody at 0.5 μg/ml dilution.
-
ARG45195 anti-DNAJC10 antibody FACS image
Flow Cytometry: Hela stained with ARG45195 anti-DNAJC10 antibody at 1 µg/10^6 cells dilution.
-
ARG45195 anti-DNAJC10 antibody WB image
Western blot: Rat stomach and RH35 stained with ARG45195 anti-DNAJC10 antibody at 0.5 μg/ml dilution.
-
ARG45195 anti-DNAJC10 antibody WB image
Western blot: Mouse stomach and HEPA1-6 stained with ARG45195 anti-DNAJC10 antibody at 0.5 μg/ml dilution.
