ARG41182
anti-DNAJB6 antibody
anti-DNAJB6 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DNAJB6 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DNAJB6 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 177-326 of Human DNAJB6 (NP_490647.1). |
| 偶联标记 | Un-conjugated |
| 別名 | LGMD1D; DJ4; Heat shock protein J2; MRJ; DnaJ homolog subfamily B member 6; HSJ-2; HHDJ1; HSJ2; LGMD1E; MSJ-1; DnaJ |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Rat brain | ||||||||
| 实际分子量 | 40 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DNAJB6 |
| 全名 | DnaJ (Hsp40) homolog, subfamily B, member 6 |
| 背景介绍 | This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] |
| 生物功能 | Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. [UniProt] |
| 细胞定位 | Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. [UniProt] |
| 预测分子量 | 36 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG41182 anti-DNAJB6 antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG41182 anti-DNAJB6 antibody.
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ARG41182 anti-DNAJB6 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue stained with ARG41182 anti-DNAJB6 antibody at 1:100 dilution.
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ARG41182 anti-DNAJB6 antibody WB image
Western blot: 25 µg of Rat brain lysate stained with ARG41182 anti-DNAJB6 antibody at 1:1000 dilution.
