ARG65651
anti-DMTF1 antibody
anti-DMTF1 antibody for Western blot and Human,Mouse,Rat
Cell Biology and Cellular Response antibody; Gene Regulation antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes DMTF1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Cow, Dog, Pig |
| 应用 | WB |
| 特异性 | This antibody is expected to recognize both reported isoforms (NP_066968.3; NP_001135798.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 靶点名称 | DMTF1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human DMTF1 (C-DAHVSKFSDQNSTE) |
| 偶联标记 | Un-conjugated |
| 別名 | hDMP1; hDMTF1; DMTF; Cyclin-D-binding Myb-like transcription factor 1; DMP1; MRUL; Cyclin-D-interacting Myb-like protein 1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DMTF1 |
| 全名 | cyclin D binding myb-like transcription factor 1 |
| 背景介绍 | This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
| 生物功能 | Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Gene Regulation antibody |
| 预测分子量 | 75 kDa (NP_001135799.1) |
| 翻译后修饰 | Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex. |
检测图片 (1) Click the Picture to Zoom In
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ARG65651 anti-DMTF1 antibody WB image
Western blot: 35 μg of Human (A), Mouse (B) and Rat (C) Testis lysate stained with ARG65651 anti-DMTF1 antibody at 1 μg/ml dilution (1 hour incubation).
