ARG65650
anti-DMRT2 antibody
anti-DMRT2 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Gene Regulation antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes DMRT2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow |
| 应用 | IHC-P |
| 特异性 | This antibody is expected to recognize isoform 2 only (NP_870987.2). Reported variants NP_001124337.1 and NP_006548.1 represent identical protein |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 靶点名称 | DMRT2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the C-terminus of Human DMRT2 (C-KRPSSAITRVSQ) |
| 偶联标记 | Un-conjugated |
| 別名 | Doublesex-like 2 protein; Doublesex- and mab-3-related transcription factor 2; DSXL-2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y5R5 Human Doublesex- and mab-3-related transcription factor 2 |
|---|---|
| 基因名称 | DMRT2 |
| 全名 | doublesex and mab-3 related transcription factor 2 |
| 背景介绍 | The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010] |
| 生物功能 | Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). [UniProt] |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 62 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG65650 anti-DMRT2 antibody IHC image
Immunohistochemistry: paraffin embedded Human Kidney stained with ARG65650 anti-DMRT2 antibody at 2 μg/ml dilution. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
