ARG43801
anti-DMP1 antibody
anti-DMP1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Developmental Biology antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DMP1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DMP1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to N-terminal of Human DMP1. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Dolichol-phosphate mannosyltransferase subunit 1 |
| 別名 | DMP-1; Dentin matrix protein 1; ARHP; Dentin matrix acidic phosphoprotein 1; ARHR |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa; Mouse Kidney; Rat liver | ||||||
| 实际分子量 | 30 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | PBS with 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DMP1 |
| 全名 | dentin matrix acidic phosphoprotein 1 |
| 背景介绍 | Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| 研究领域 | Developmental Biology antibody; Signaling Transduction antibody |
| 预测分子量 | 30 kDa |
| 翻译后修饰 | Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif. |
检测图片 (4) Click the Picture to Zoom In
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ARG43801 anti-DMP1 antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG43801 anti-DMP1 antibody at 1:100 dilution.
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ARG43801 anti-DMP1 antibody WB image
Western Blot: HeLa cell lysate stained with ARG43801 anti-DMP1 antibody at 1:1000 dilution.
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ARG43801 anti-DMP1 antibody WB image
Western Blot: Rat liver tissue lysate stained with ARG43801 anti-DMP1 antibody at 1:1000 dilution.
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ARG43801 anti-DMP1 antibody WB image
Western Blot: Mouse kidneytissue lysate stained with ARG43801 anti-DMP1 antibody at 1:1000 dilution.
