ARG42391
anti-DLL4 antibody [MHD4-46] (low endotoxin)
anti-DLL4 antibody [MHD4-46] (low endotoxin) for Flow cytometry,Functional study and Human
概述
| 产品描述 | Azide free and low endotoxin Mouse Monoclonal antibody [MHD4-46] recognizes DLL4 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, FuncSt |
| 特异性 | The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MHD4-46 |
| 同位型 | IgG1, kappa |
| 靶点名称 | DLL4 |
| 抗原物种 | Human |
| 抗原 | Recombinant soluble Human DLL4. |
| 偶联标记 | Un-conjugated |
| 別名 | Drosophila Delta homolog 4; hdelta2; Delta4; Delta-like protein 4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 纯化说明 | 0.2 µm filter sterilized. Endotoxin level is <0.01 EU/µg of the protein. |
| 缓冲液 | PBS |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DLL4 |
| 全名 | delta-like 4 (Drosophila) |
| 背景介绍 | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 75 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42391 anti-DLL4 antibody [MHD4-46] (low endotoxin) FACS image
Flow Cytometry: DLL4-transfected HD4 cells stained with ARG42391 anti-DLL4 antibody [MHD4-46] (low endotoxin), followed by APC-conjugated Goat anti-Mouse antibody.
