概述

产品描述	Rabbit Polyclonal antibody recognizes DISC1
反应物种	Hu, Ms
应用	ICC/IF, IP, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	DISC1
抗原物种	Human
抗原	Synthetic peptide corresponding to aa. 74-91 of Human DISC1. (EESHHSESRARQCGLDSR)
偶联标记	Un-conjugated
別名	Disrupted in schizophrenia 1 protein; SCZD9; C1orf136

应用说明

应用建议	应用 推荐稀释比 ICC/IF Assay-dependent IP Assay-dependent WB 0.1 - 0.5 µg/ml
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量	~ 95 kDa

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA.
抗菌剂	0.05% Thimerosal and 0.05% Sodium azide
稳定剂	5% BSA
浓度	0.5 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 244667 Mouse DISC1 GeneID: 27185 Human DISC1 Swiss-port # Q811T9 Mouse Disrupted in schizophrenia 1 homolog Swiss-port # Q9NRI5 Human Disrupted in schizophrenia 1 protein
基因名称	DISC1
全名	disrupted in schizophrenia 1
背景介绍	This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
生物功能	Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. [UniProt]
细胞定位	Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome. [UniProt]
预测分子量	94 kDa

检测图片 (1) Click the Picture to Zoom In