ARG45063
anti-DIAPH3 antibody
anti-DIAPH3 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DIAPH3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DIAPH3 |
| 抗原物种 | Human |
| 抗原 | DIAPH3 synthetic peptide corresponding to amino acid residues near the C-terminus of human DIAPH3. This peptide sequence is highly conserved in rat and mouse DIAPH3, and has low homology to other formins. |
| 偶联标记 | Un-conjugated |
| 別名 | DIAPH3; Diaphanous Related Formin 3; DRF3; NSDAN; AN; Protein Diaphanous Homolog 3; FLJ34705; AUNA1; MDia2; Auditory Neuropathy, Autosomal Dominant 1; Diaphanous (Drosophila, Homolog) 3; Diaphanous Homolog 3 (Drosophila); Diaphanous-Related Formin-3; Diaphanous Homolog 3; Diap3; DIAP3; DIA2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified. |
| 缓冲液 | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| 稳定剂 | 50% Glycerol and 0.1 % BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DIAPH3 |
| 全名 | Diaphanous Related Formin 3 |
| 背景介绍 | This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| 生物功能 | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. [Uniprot] |
| 细胞定位 | Cytoplasm, Nucleus. [Uniprot] |
| 预测分子量 | 137 kDa |
| 翻译后修饰 | Phosphoprotein, Ubl conjugation. [Uniprot] |
