ARG55182
anti-DCLK1 antibody
anti-DCLK1 antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Neuroscience antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DCLK1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DCLK1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide (14 aa) within the last 50 aa of Human DCLK1. |
| 偶联标记 | Un-conjugated |
| 別名 | DCAMKL1; DCLK; Serine/threonine-protein kinase DCLK1; Doublecortin-like and CAM kinase-like 1; DCDC3A; EC 2.7.11.1; Doublecortin domain-containing protein 3A; CL1; Doublecortin-like kinase 1; CLICK1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Human Brain Tissue Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O15075 Human Serine/threonine-protein kinase DCLK1 Swiss-port # Q9JLM8 Mouse Serine/threonine-protein kinase DCLK1 |
|---|---|
| 基因名称 | DCLK1 |
| 全名 | doublecortin-like kinase 1 |
| 背景介绍 | DCLK1 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK1 mRNA, like that of the homologous DCLK2 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a gene that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice. |
| 生物功能 | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. [UniProt] |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 82 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG55182 anti-DCLK1 antibody WB image
Western blot: human brain tissue lysate stained with ARG55182 anti-DCLK1 antibody at (A) 0.5 and (B) 1 ug/ml dilution.
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ARG55182 anti-DCLK1 antibody IHC image
Immunohistochemistry: DLCK1 in rat brain tissue stained with ARG55182 anti-DCLK1 antibody at 2.5 ug/ml dilution.
