ARG55196
anti-DCK antibody
anti-DCK antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cancer antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DCK |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DCK |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human DCK (NP_000779.1) |
| 偶联标记 | Un-conjugated |
| 別名 | EC 2.7.1.74; Deoxycytidine kinase; dCK |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Raji |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DCK |
| 全名 | deoxycytidine kinase |
| 背景介绍 | Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008] |
| 生物功能 | Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. [UniProt] |
| 研究领域 | Cancer antibody; Signaling Transduction antibody |
| 预测分子量 | 31 kDa |
| 翻译后修饰 | Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1. |
检测图片 (3) Click the Picture to Zoom In
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ARG55196 anti-DCK antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG55196 anti-DCK antibody.
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ARG55196 anti-DCK antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat kidney stained with ARG55196 anti-DCK antibody at 1:100 dilution.
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ARG55196 anti-DCK antibody WB image
Western blot: Raji cell lysate stained with ARG55196 anti-DCK antibody.
