ARG58491
anti-DBI antibody
anti-DBI antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DBI |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DBI |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-114 of Human DBI (NP_001171513.1). |
| 偶联标记 | Un-conjugated |
| 別名 | DBI; ACBP; Acyl-CoA-binding protein; Endozepine; ACBD1; Diazepam-binding inhibitor; CCK-RP; EP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | NCI-H460 | ||||||||||
| 实际分子量 | 11 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DBI |
| 全名 | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) |
| 背景介绍 | This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. [UniProt] |
| 细胞定位 | Endoplasmic reticulum, Golgi apparatus. [UniProt] |
| 预测分子量 | 10 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG58491 anti-DBI antibody ICC/IF image
Immunofluorescence: MCF-7 cells stained with ARG58491 anti-DBI antibody.
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ARG58491 anti-DBI antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human prostate stained with ARG58491 anti-DBI antibody at 1:100 dilution.
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ARG58491 anti-DBI antibody WB image
Western blot: 25 µg of NCI-H460 cell lysate stained with ARG58491 anti-DBI antibody at 1:1000 dilution.
