ARG22860
anti-DAZL antibody [3/11A]
anti-DAZL antibody [3/11A] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Monkey
概述
| 产品描述 | Mouse Monoclonal antibody [3/11A] recognizes DAZL Mouse anti Human DAZL antibody, clone 3/11A recognizes human Deleted in azoospermia-like, also known as DAZL, DAZ homolog, DAZ-like autosomal, Deleted in azoospermia-like 1 or SPGY-like-autosomal. DAZL is a 295 amino acid ~33 kDa member of the DAZ (deleted in azoospermia) family of RNA binding proteins. DAZL is expressed in fetal and adult testes and ovaries, and is believed to play a role in germ cell development. In adult germ cells, the expression of DAZL is predominantly localized to the cytoplasm.Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. |
|---|---|
| 反应物种 | Hu, Ms, Rat, Mk |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 3/11A |
| 同位型 | IgG1 |
| 靶点名称 | DAZL |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the C-terminus of Human DAZL. (CRVHHFRRSRAMLKSV) |
| 偶联标记 | Un-conjugated |
| 別名 | DAZL1; SPGYLA; Deleted in azoospermia-like; Deleted in azoospermia-like 1; SPGY-like-autosomal; DAZLA; DAZH; DAZ homolog; DAZ-like autosomal |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in Sodium citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Tissue Culture Supernatant. |
| 缓冲液 | Tissue Culture Supernatant and 0.09% Sodium azide, |
| 抗菌剂 | 0.09% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DAZL |
| 全名 | deleted in azoospermia-like |
| 背景介绍 | The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| 生物功能 | RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). [UniProt] |
| 预测分子量 | 33 kDa |
