概述

产品描述	Mouse Monoclonal antibody [5D3] recognizes DAAM1
反应物种	Hu, Ms, Rat
应用	ICC/IF, WB
宿主	Mouse
克隆	Monoclonal
克隆号	5D3
同位型	IgG2a
靶点名称	DAAM1
抗原物种	Human
抗原	Clone 5D3 was generated from a recombinant protein that included amino acid residues from the N-terminal region of human DAAM1. This sequence has less than 50% homology to the N-terminal region of DAAM2.
偶联标记	Un-conjugated
別名	DAAM1; Dishevelled Associated Activator Of Morphogenesis 1; KIAA0666; Disheveled-Associated Activator Of Morphogenesis 1

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:100 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Antigen Affinity Purified.
缓冲液	PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA.
稳定剂	50% Glycerol and 0.1 % BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 208846 Mouse DAAM1 GeneID: 23002 Human DAAM1 Swiss-port # Q8BPM0 Mouse Disheveled-associated activator of morphogenesis 1 Swiss-port # Q9Y4D1 Human Disheveled-associated activator of morphogenesis 1
基因名称	DAAM1
全名	Dishevelled Associated Activator Of Morphogenesis 1
背景介绍	Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
生物功能	During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. [Uniprot]
细胞定位	Cell projection, Cytoplasm, Cytoskeleton. [Uniprot]
预测分子量	123 kDa
翻译后修饰	Phosphoprotein. [Uniprot]

检测图片 (1) Click the Picture to Zoom In