ARG40226
anti-Cytokeratin 10 antibody
anti-Cytokeratin 10 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Cytokeratin 10 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Cytokeratin 10 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human Cytokeratin 10. |
| 偶联标记 | Un-conjugated |
| 別名 | KPP; K10; CK-10; BIE; Keratin, type I cytoskeletal 10; Cytokeratin-10; CK10; BCIE; Keratin-10; EHK |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | A431 | ||||||||
| 实际分子量 | ~ 55 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KRT10 |
| 全名 | keratin 10, type I |
| 背景介绍 | Cytokeratin 10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cytokeratin 10 plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. [UniProt] |
| 细胞定位 | Secreted, extracellular space. Note=Localized on the surface of desquamated nasal epithelial cells. [UniProt] |
| 预测分子量 | 59 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG40226 anti-Cytokeratin 10 antibody ICC/IF image
Immunofluorescence: HaCaT cells stained with ARG40226 anti-Cytokeratin 10 antibody.
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ARG40226 anti-Cytokeratin 10 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human bladder stained with ARG40226 anti-Cytokeratin 10 antibody.
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ARG40226 anti-Cytokeratin 10 antibody WB image
Western blot: A431 cell lysate stained with ARG40226 anti-Cytokeratin 10 antibody.
