ARG43846
anti-Cyclin D1 antibody [DCS-6] (Biotin)
anti-Cyclin D1 antibody [DCS-6] (Biotin) for Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Biotin-conjugated Mouse Monoclonal antibody recognizes Cyclin D1. |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, NHuPrm |
| 应用 | FACS, IHC-Fr, IHC-P, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | DCS-6 |
| 同位型 | IgG2a |
| 靶点名称 | Cyclin D1 |
| 抗原物种 | Human |
| 抗原 | Human Cyclin D1 recombinant protein. |
| 偶联标记 | Biotin |
| Protein Full name | G1/S-specific cyclin-D1 |
| 別名 | CCND1; Cyclin D1; U21B31; PRAD1; BCL1; B-Cell Lymphoma 1 Protein; G1/S-Specific Cyclin-D1; B-Cell CLL/Lymphoma 1; BCL-1 Oncogene; PRAD1 Oncogene; D11S287E; Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1); Parathyroid Adenomatosis 1; G1/S-Specific Cyclin D1; BCL-1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein-A affinity chromatography |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 4°C. Keep protected from prolonged exposure to light. Do not freeze. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CCND1 |
| 全名 | Cyclin D1 |
| 背景介绍 | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019] |
| 生物功能 | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. |
| 细胞定位 | Cytoplasm, Membrane, Nucleus |
| 预测分子量 | 34 kDa |
| 翻译后修饰 | Isopeptide bond; Phosphoprotein; Ubl conjugation |
检测图片 (1) Click the Picture to Zoom In
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ARG43846 anti-Cyclin D1 antibody [DCS-6] (Biotin) FACS image
Flow Cytometry: MCF-7 stained with ARG43846 anti-Cyclin D1 antibody [DCS-6] (Biotin) at 5 μg/ml.
