ARG57587
anti-Cubilin antibody
anti-Cubilin antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Cubilin |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Cubilin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide from Human Cubilin. |
| 偶联标记 | Un-conjugated |
| 別名 | Intrinsic factor-vitamin B12 receptor; Cubilin; Intrinsic factor-cobalamin receptor; IFCR; Intestinal intrinsic factor receptor; MGA1; gp280; 460 kDa receptor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CUBN |
| 全名 | cubilin (intrinsic factor-cobalamin receptor) |
| 背景介绍 | Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. [UniProt] |
| 预测分子量 | 399 kDa |
| 翻译后修饰 | The precursor is cleaved by a trans-Golgi proteinase furin. The result is a propeptide cleaved off. N-glycosylated. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG57587 anti-Cubilin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue stained with ARG57587 anti-Cubilin antibody.
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ARG57587 anti-Cubilin antibody WB image
Western blot: Human fetal kidney lysate stained with ARG57587 anti-Cubilin antibody.
