ARG45506
anti-CtIP antibody
anti-CtIP antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CtIP |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CtIP |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human CtIP. |
| 偶联标记 | Un-conjugated |
| 別名 | RBBP8; RB Binding Protein 8, Endonuclease; RIM; COM1; CTIP; Sporulation In The Absence Of SPO11 Protein 2 Homolog; Retinoblastoma-Binding Protein 8; Retinoblastoma Binding Protein 8; CTBP-Interacting Protein; DNA Endonuclease RBBP8; RBBP-8; SCKL2; CtIP; SAE2; Retinoblastoma-Interacting Protein And Myosin-Like; CtBP-Interacting Protein; Seckel Syndrome 2; EC 3.1.-.- ; JAWAD; JWDS |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | RBBP8 |
| 全名 | RB Binding Protein 8, Endonuclease |
| 背景介绍 | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. |
| 生物功能 | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. [UniProt] |
| 细胞定位 | Chromosome; Nucleus. [UniProt] |
| 预测分子量 | 102 kDa |
| 翻译后修饰 | Isopeptide bond; Phosphoprotein; Ubl conjugation. [UniProt] |
检测图片 (5) Click the Picture to Zoom In
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ARG45506 anti-CtIP antibody IHC-P image
Immunohistochemistry: Human endometrioid adenocarcinoma stained with ARG45506 anti-CtIP antibody at 2 μg/ml dilution.
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ARG45506 anti-CtIP antibody ICC/IF image
Immunofluorescence: Hela stained with ARG45506 anti-CtIP antibody at 5 μg/ml dilution.
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ARG45506 anti-CtIP antibody WB image
Western blot: Raji stained with ARG45506 anti-CtIP antibody at 0.5 μg/ml dilution.
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ARG45506 anti-CtIP antibody FACS image
Flow Cytometry: MCF-7 stained with ARG45506 anti-CtIP antibody at 1 µg/10^6 cells dilution.
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ARG45506 anti-CtIP antibody WB image
Western blot: Mouse testis stained with ARG45506 anti-CtIP antibody at 0.5 μg/ml dilution.
