概述

产品描述	Rabbit Polyclonal antibody recognizes CtIP phospho (Ser327)
反应物种	Hu
预测物种	NHuPrm
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	CtIP
抗原物种	Human
抗原	Synthetic phospho-peptide
偶联标记	Un-conjugated
別名	RBBP8; RB Binding Protein 8, Endonuclease; RIM; COM1; CTIP; Sporulation In The Absence Of SPO11 Protein 2 Homolog; Retinoblastoma-Binding Protein 8; Retinoblastoma Binding Protein 8; CTBP-Interacting Protein; DNA Endonuclease RBBP8; RBBP-8; SCKL2; CtIP; SAE2; Retinoblastoma-Interacting Protein And Myosin-Like; CtBP-Interacting Protein; Seckel Syndrome 2; EC 3.1.-.- ; JAWAD; JWDS

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Antigen Affinity Purified
缓冲液	10 mM HEPES (pH 7.5), 150 mM NaCl, 50% Glycerol and 100 µg/ml BSA.
稳定剂	50% Glycerol and 100 µg/ml BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 5932 Human RBBP8 Swiss-port # Q99708 Human DNA endonuclease RBBP8
基因名称	RBBP8
全名	RB Binding Protein 8, Endonuclease
背景介绍	The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
生物功能	Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway.
细胞定位	Chromosome, Nucleus
预测分子量	102 kDa
翻译后修饰	Isopeptide bond, Phosphoprotein, Ubl conjugation

检测图片 (1) Click the Picture to Zoom In