概述

产品描述	Mouse Monoclonal antibody [M332] recognizes CrkII
反应物种	Hu, Ms, Rat
应用	IP, WB
宿主	Mouse
克隆	Monoclonal
克隆号	M332
同位型	IgG1
靶点名称	CrkII
抗原物种	Mouse
抗原	[M332] was generated from a recombinant sequence containing the C-terminal half of mouse Crk II.
偶联标记	Un-conjugated
別名	CRK; CRK Proto-Oncogene, Adaptor Protein; V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog; Adapter Molecule Crk; Proto-Oncogene C-Crk; P38; V-Crk Sarcoma Virus CT10 Oncogene-Like Protein; CRKII

应用说明

应用建议	应用 推荐稀释比 IP 1:50 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Protein A Purified.
缓冲液	PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA.
稳定剂	50% Glycerol and 0.1 % BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 12928 Mouse CRK GeneID: 1398 Human CRK GeneID: 54245 Rat CRK Swiss-port # P46108 Human Adapter molecule crk Swiss-port # Q63768 Rat Adapter molecule crk Swiss-port # Q64010 Mouse Adapter molecule crk More
基因名称	CRK
全名	CRK Proto-Oncogene, Adaptor Protein
背景介绍	This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
生物功能	Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. [Uniprot]
细胞定位	Cell membrane, Cytoplasm, Membrane. [Uniprot]
预测分子量	34 kDa
翻译后修饰	Acetylation, Phosphoprotein. [Uniprot]

检测图片 (1) Click the Picture to Zoom In