ARG23995
anti-Collagen V antibody
anti-Collagen V antibody for ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Bovine,Pig
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Collagen V |
|---|---|
| 反应物种 | Hu, Bov, Pig |
| 应用 | ELISA, ICC/IF, IHC-P, WB |
| 特异性 | Cross-reactivity with Bovine and porcine species. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Collagen V |
| 抗原物种 | Human |
| 抗原 | Type V collagen extracted from Human placenta. |
| 偶联标记 | Un-conjugated |
| 別名 | EDSC; Collagen alpha-1(V) chain |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: treat sections with 0.5% hyaluronidase at RT for 1hr before staining. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | COL5A1 |
| 全名 | collagen, type V, alpha 1 |
| 背景介绍 | This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] |
| 生物功能 | Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. [UniProt] |
| 细胞定位 | Secreted, extracellular space, extracellular matrix. [UniProt] |
| 预测分子量 | 184 kDa |
| 翻译后修饰 | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Sulfated on 40% of tyrosines. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG23995 anti-Collagen V antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human skin tissue stained with ARG23995 anti-Collagen V antibody.
