ARG24020
anti-Collagen II antibody
anti-Collagen II antibody for ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse,Bovine
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Collagen II |
|---|---|
| 反应物种 | Ms, Bov |
| 应用 | ELISA, ICC/IF, IHC-P, WB |
| 特异性 | Cross-reactivity with Bovine type II collagen, Murine type II collagen and Murine procollagen. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Collagen II |
| 抗原物种 | Mouse |
| 抗原 | Native type II collagen extracted from Mouse. |
| 偶联标记 | Un-conjugated |
| 別名 | AOM; ANFH; SEDC; STL1; COL11A3; Collagen alpha-1(II) chain; Alpha-1 type II collagen) |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: treat sections with 0.5% hyaluronidase at RT for 1hr before staining. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | COL2A1 |
| 全名 | collagen, type II, alpha 1 |
| 背景介绍 | This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. [UniProt] |
| 细胞定位 | Secreted, extracellular space, extracellular matrix. [UniProt] |
| 预测分子量 | 142 kDa |
| 翻译后修饰 | Probably 3-hydroxylated on prolines by LEPREL1 (By similarity). Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains. The N-telopeptide is covalently linked to the helical COL2 region of alpha 1(IX), alpha 2(IX) and alpha 3(IX) chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3(IX) COL2. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG24020 anti-Collagen II antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse cartilage tissue stained with ARG24020 anti-Collagen II antibody.
