ARG66487
anti-Claudin 4 antibody
anti-Claudin 4 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes Claudin 4 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2b, kappa |
| 靶点名称 | Claudin 4 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human Claudin 4. |
| 偶联标记 | Un-conjugated |
| 別名 | CPE-R; Williams-Beuren syndrome chromosomal region 8 protein; hCPE-R; CPE-receptor; CPETR; CPETR1; Clostridium perfringens enterotoxin receptor; Claudin-4; CPER; WBSCR8 |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Tris/EDTA buffer (pH 8.0) was used. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 实际分子量 | ~ 20 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CLDN4 |
| 全名 | claudin 4 |
| 背景介绍 | The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013] |
| 生物功能 | Plays a major role in tight junction-specific obliteration of the intercellular space. [UniProt] |
| 细胞定位 | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=CLDN4 is required for tight junction localization in the kidney. [UniProt] |
| 预测分子量 | 22 kDa |
| 翻译后修饰 | Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG66487 anti-Claudin 4 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human colon stained with ARG66487 anti-Claudin 4 antibody at 1:200 (4°C, overnight). Antigen Retrieval: Tris/EDTA buffer (pH 8.0) was used.
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ARG66487 anti-Claudin 4 antibody WB image
Western blot: 30 µg of LnCap whole cell lysate stained with ARG66487 anti-Claudin 4 antibody at 1:1000 dilution.
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ARG66487 anti-Claudin 4 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human pancreatic carcinoma stained with ARG66487 anti-Claudin 4 antibody at 1:200 (4°C, overnight). Antigen Retrieval: Tris/EDTA buffer (pH 8.0) was used.
