ARG41696
anti-Claudin 18 antibody
anti-Claudin 18 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Claudin 18 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog, Gpig, Hrs, Rb |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Claudin 18 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the C-terminal region of Human Claudin 18. (within the following region: PEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDE) |
| 偶联标记 | Un-conjugated |
| 別名 | Claudin-18; SFTPJ; SFTA5 |
应用说明
| 预测反应性说明 | Predicted Homology Based On Immunogen Sequence: Cow: 85%; Dog: 79%; Guinea pig: 92%; Horse: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100% | ||||
|---|---|---|---|---|---|
| 应用建议 |
|
||||
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Jurkat | ||||
| 实际分子量 | ~ 28 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CLDN18 |
| 全名 | claudin 18 |
| 背景介绍 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010] |
| 生物功能 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. [UniProt] |
| 细胞定位 | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 28 kDa |
检测图片 (2) Click the Picture to Zoom In
-
ARG41696 anti-Claudin 18 antibody WB image
Western blot: Jurkat cell lysate stained with ARG41696 anti-Claudin 18 antibody at 1 µg/ml dilution.
-
ARG41696 anti-Claudin 18 antibody WB image
Western blot: 25 µg of Jurkat cell lysates stained with ARG41696 anti-Claudin 18 antibody at 1 µg/ml dilution. The antibody was used in the presence (right) or the absence (left) of blocking peptide.
