ARG22278
anti-Cav 1.3 antibody [S48A-9]
anti-Cav 1.3 antibody [S48A-9] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [S48A-9] recognizes Cav 1.3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 特异性 | Detects ~250kDa. No cross-reactivity against Cav1.2. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S48A-9 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | Cav 1.3 |
| 抗原物种 | Rat |
| 抗原 | Fusion protein around aa. 859-875 of Rat CaV1.3 |
| 偶联标记 | Un-conjugated |
| 別名 | SANDD; CCHL1A2; Cav1.3; CACN4; PASNA; CACNL1A2; Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-dependent L-type calcium channel subunit alpha-1D; CACH3; Voltage-gated calcium channel subunit alpha Cav1.3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Cacna1d |
| 全名 | calcium channel, voltage-dependent, L type, alpha 1D subunit |
| 背景介绍 | Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] |
| 生物功能 | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). [UniProt] |
| 细胞定位 | Cell membrane, Membrane |
| 预测分子量 | 245 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG22278 anti-Cav 1.3 antibody [S48A-9] ICC/IF image
Immunofluorescence: Neuroblastoma cell stained with ARG22278 anti-Cav 1.3 antibody [S48A-9] (red) at 1:50 dilution.
