ARG45335
anti-Cathepsin L / MEP antibody [5G14]
anti-Cathepsin L / MEP antibody [5G14] for IHC-Formalin-fixed paraffin-embedded sections and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [5G14] recognizes Cathepsin L / MEP |
|---|---|
| 反应物种 | Ms |
| 应用 | IHC-P |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 5G14 |
| 同位型 | IgG2 |
| 靶点名称 | Cathepsin L / MEP |
| 抗原物种 | Mouse |
| 抗原 | Recombinant Mouse Cathepsin L / MEP. |
| 偶联标记 | Un-conjugated |
| 別名 | CTSL; Cathepsin L; Cathepsin L1; CTSL1; Major Excreted Protein; Procathepsin L; EC; FLJ31037; MEP; CATL |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G/A chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CTSL |
| 全名 | Cathepsin L |
| 背景介绍 | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020] |
| 生物功能 | Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. [UniProt] |
| 细胞定位 | Cell membrane; Cytoplasmic vesicle; Lysosome; Membrane; Nucleus; Secreted. [UniProt] |
| 预测分子量 | 38 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Zymogen. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45335 anti-Cathepsin L / MEP antibody [5G14] IHC-P image
Immunohistochemistry: Mouse kidney stained with ARG45335 anti-Cathepsin L / MEP antibody [5G14].
