ARG43117
anti-Cathepsin K antibody
anti-Cathepsin K antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Cathepsin K |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Cathepsin K |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to A115-M329 of Human Cathepsin K. |
| 偶联标记 | Un-conjugated |
| 別名 | Cathepsin X; CTS02; CTSO; PYCD; Cathepsin O; PKND; EC 3.4.22.38; Cathepsin K; Cathepsin O2; CTSO1; CTSO2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa and 22Rv1 | ||||||
| 实际分子量 | ~ 45 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CTSK |
| 全名 | cathepsin K |
| 背景介绍 | The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013] |
| 生物功能 | Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. [UniProt] |
| 细胞定位 | Lysosome. [UniProt] |
| 预测分子量 | 37 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG43117 anti-Cathepsin K antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human osteosarcoma tissue stained with ARG43117 anti-Cathepsin K antibody at 1 µg/ml dilution.
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ARG43117 anti-Cathepsin K antibody WB image
Western blot: HeLa and 22Rv1 whole cell lysates stained with ARG43117 anti-Cathepsin K antibody at 0.5 µg/ml dilution.
