概述

产品描述	Rabbit Polyclonal antibody recognizes Cathepsin B
反应物种	Hu
应用	ICC/IF, IHC-P, IP, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	Cathepsin B
抗原物种	Human
抗原	Synthetic peptide derived from Human Cathepsin B.
偶联标记	Un-conjugated
別名	EC 3.4.22.1; Cathepsin B; APPS; CPSB; APP secretase; Cathepsin B1

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:50 - 1:200 IHC-P 1:50 - 1:200 IP 1:50 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量	38 kDa

属性

形式	Liquid
纯化	Affinity purified
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1508 Human CTSB Swiss-port # P07858 Human Cathepsin B
基因名称	CTSB
全名	cathepsin B
背景介绍	The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
生物功能	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. [UniProt]
细胞定位	Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. [UniProt]
预测分子量	38 kDa

检测图片 (1) Click the Picture to Zoom In