ARG65649
anti-Caspase 6 antibody
anti-Caspase 6 antibody for Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Neuroscience antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes Caspase 6 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | This antibody is expected to recognize both reported isoforms (NP_001217.2; NP_116787.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 靶点名称 | Caspase 6 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human Caspase-6 (C-QTEKLDTNITEVD) |
| 偶联标记 | Un-conjugated |
| 別名 | MCH2; EC 3.4.22.59; CASP-6; Caspase-6; Apoptotic protease Mch-2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CASP6 |
| 全名 | caspase 6, apoptosis-related cysteine peptidase |
| 背景介绍 | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015] |
| 生物功能 | Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Neuroscience antibody |
| 预测分子量 | 33.3 kDa (NP_001217.2) |
| 翻译后修饰 | Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits. |
检测图片 (1) Click the Picture to Zoom In
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ARG65649 anti-Caspase 6 antibody WB image
Western blot: 35 μg of Human Colon lysate stained with ARG65649 anti-Caspase 6 antibody at 0.3 μg/ml dilution (1 hour incubation).
