ARG41706
anti-Caspase 5 antibody
anti-Caspase 5 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Caspase 5 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Caspase 5 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human Caspase 5. |
| 偶联标记 | Un-conjugated |
| 別名 | Protease ICH-3; Caspase-5; Protease TY; CASP-5; EC 3.4.22.58; ICE; ICEREL-III; ICH-3; ICE(rel)III; rel |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | ~ 46 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CASP5 |
| 全名 | caspase 5, apoptosis-related cysteine peptidase |
| 背景介绍 | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010] |
| 生物功能 | Mediator of programmed cell death (apoptosis). [UniProt] |
| 预测分子量 | 50 kDa |
| 翻译后修饰 | The two subunits are derived from the precursor sequence by an autocatalytic mechanism. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG41706 anti-Caspase 5 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast cancer tissue stained with ARG41706 anti-Caspase 5 antibody.
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ARG41706 anti-Caspase 5 antibody WB image
Western blot: HeLa cell lysate stained with ARG41706 anti-Caspase 5 antibody.
