ARG55178
anti-Caspase 4 antibody
anti-Caspase 4 antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Caspase 4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Bov |
| 应用 | ELISA, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Caspase 4 |
| 抗原物种 | Bovine |
| 抗原 | Synthetic peptide (15 aa) within aa. 80-130 of Bovine Caspase-13. |
| 偶联标记 | Un-conjugated |
| 別名 | Mih1/TX; Protease ICH-2; Caspase-4; EC 3.4.22.57; TX; CASP-4; Protease TX; ICE; ICH-2; ICE(rel)II; rel; ICEREL-II |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HL60 Cell Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Ion exchange chromatography purified. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CASP4 |
| 全名 | caspase 4, apoptosis-related cysteine peptidase |
| 背景介绍 | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines. |
| 生物功能 | Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody |
| 预测分子量 | 43 kDa |
| 翻译后修饰 | In response to activation signals, including endoplasmic reticulum stress or treatment with amyloid beta A4 protein fragments (such as beta-amyloid protein 40), undergoes autoproteolytic cleavage. |
检测图片 (2) Click the Picture to Zoom In
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ARG55178 anti-Caspase 4 antibody WB image
Western blot: Human HL60 cell lysate (A), Mouse brain (B) and Rat brain (C) tissue lysates stained with ARG55178 anti-Caspase 4 antibody at 1 ug/ml dilution.
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ARG55178 anti-Caspase 4 antibody IHC image
Immunohistochemistry: caspase-13 in Mouse brain tissue stained with ARG55178 anti-Caspase 4 antibody at 10 ug/ml dilution.
