ARG54655
anti-Caspase 4 antibody
anti-Caspase 4 antibody for ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Caspase 4 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ELISA, ICC/IF, IHC-P, WB |
| 特异性 | Depending on cell lines or tissues used, other cleavage products may be observed. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Caspase 4 |
| 抗原 | Synthetic peptide (16 aa) within aa. 20-70 of Human Caspase-4. |
| 偶联标记 | Un-conjugated |
| 別名 | Mih1/TX; Protease ICH-2; Caspase-4; EC 3.4.22.57; TX; CASP-4; Protease TX; ICE; ICH-2; ICE(rel)II; rel; ICEREL-II |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | Ramos Cell Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CASP4 |
| 全名 | caspase 4, apoptosis-related cysteine peptidase |
| 背景介绍 | Caspase-4 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease. | |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody |
| 预测分子量 | 43 kDa |
| 翻译后修饰 | In response to activation signals, including endoplasmic reticulum stress or treatment with amyloid beta A4 protein fragments (such as beta-amyloid protein 40), undergoes autoproteolytic cleavage. |
检测图片 (3) Click the Picture to Zoom In
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ARG54655 anti-Caspase 4 antibody ICC/IF image
Immunofluorescence: Mouse spleen 100 cells stained with ARG54655 anti-Caspase 4 antibody at 10 μg/ml.
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ARG54655 anti-Caspase 4 antibody IHC image
Immunohistochemistry: Mouse spleen stained with ARG54655 anti-Caspase 4 antibody at 2 μg/ml.
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ARG54655 anti-Caspase 4 antibody WB image
Western blot: Ramos cells stained with ARG54655 anti-Caspase 4 antibody at (A) 0.5 and (B) 1 μg/ml.
